In his political career, Dost Khosa was first elected as MPA when his father vacated provincial seat after taking oath as Punjab Governor in August 1999. He had also served as UC Nazim of Churratta, D.G. Khan and later as Naib District Nazim D.G. Khan till contest of general election-2008. Dost Muhammad Khosa was PML-N, DG Khan, district President for the last eight years and was arrested many times during this period on political grounds.app
Family
Dost Muhammad Khosa is the son of former Punjab Governor Sardar Zulfiqar Ali Khan Khosa. He is the youngest of three brothers.