Diethylpropion

Diethylpropion
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Diethylcathinone
Systematic (IUPAC) name
2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number	90-84-6
ATC code	A08AA03
PubChem	7029
Chemical data
Formula	C₁₃H₁₉N O
Mol. mass	205.30
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	B
Legal status	Schedule IV(US)
Routes	?

Diethylcathinone (also called Diethylpropion and Amfepramone), is a sympathomimetic stimulant drug marketed as an appetite suppressant. It is sold under the brand name Tenuate or Tenuate Dospan, and may also be known as Amfepramone. The popular antidepressant, Wellbutrin (bupropion) is an analogue of this chemical. Both diethylpropion and bupropion have a stimulant effect on the CNS.

1 Pharmacology
2 Contraindications
3 Side effects
4 See also
5 References

Pharmacology

Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl homologue of cathinone and dimethylcathinone. It has been found to be potentially neurotoxic in that it causes long-term depletions of 5-HT similar to MDMA.^[1]

Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate, Tepanil Ten-Tab). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

Contraindications

Hypersensitivity to sympathomimetic amines
Advanced arteriosclerosis or symptomatic cardiovascular disease
Moderate or severe hypertension
Hyperthyroidism
History of drug abuse
MAO inhibitor use (within 14 days)

Side effects

Severe

Insomnia
Pulmonary hypertension
Stroke
Psychosis

Cardiovascular

Tachycardia, hypertension, arrhythmia, chest pain

Ear, nose, and throat

Xerostomia, metallic taste

Endocrine

Changes in libido, gynecomastia, menstrual irregularities

Eye

Blurred vision

Gastrointestinal

Nausea/vomiting, constipation, abdominal cramps

Hematological

Bone marrow depression, agranulocytosis, leukopenia

Neurological

Tremor

Psychological

Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures

Skin

Rash, hives, alopecia, ecchymosis

Urogenital and reproductive

Changes in libido, impotence

References

^ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301

v • d • e Stimulants

Alkylamines	Cyclopentamine • Geranamine • Isometheptene • Octodrine • Propylhexedrine • Tuamine

Alphapyrrolidinylalkiophenones	α-PPP • MDPPP • MDPV • MPHP • MPPP • MOPPP • Pyrovalerone

Cholinergics	ABT-089 • ABT-418 • Anabasine • Arecoline • Cotinine • Cytisine • Dianicline • Epibatidine • Epiboxidine • GTS-21 • Ispronicline • Nicotine • Rivanicline • Tebanicline • Varenicline

Convulsants	Bicuculline • DMCM • Gabazine • Pentetrazol • Picrotoxin • Strychnine • Thujone

Eugeroics	Adrafinil • Armodafinil • Carphedon • Modafinil

Phenethylamines	4-Bromomethcathinone • 4-Fluoroamphetamine • 4-Fluoromethamphetamine • 4-Fluoromethcathinone • 4-Methylmethcathinone • 4-MTA • Aletamine • Amfepentorex • Amphechloral • Amphetamine (Dextroamphetamine, Adderall) • Amphetaminil • Benzphetamine • Bupropion • Cathinone • Chlorphentermine • Clenbuterol • Clobenzorex • Clortermine • Diethylpropion • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone • Ephedrine • Epinephrine • Ethcathinone • Ethylamphetamine • Fenethylline • Fenfluramine • Fenproporex • Fludorex • Furfenorex • Levomethamphetamine • Lisdexamfetamine • MDMA • Mefenorex • Methamphetamine • Methcathinone • Methoxyphedrine • Methylone • Octopamine • Ortetamine • Parahydroxyamphetamine • PCA • PIA • PMA • PMEA • PMMA • PPAP • Phendimetrazine • Phenmetrazine • Phentermine • Phenylephrine • Phenylpropanolamine • Propylamphetamine • Pseudoephedrine • Selegiline • Synephrine • Xylopropamine

Phenylaminooxazoles	4-Methyl-aminorex • Aminorex • Clominorex • Fenozolone • Fluminorex • Pemoline • Thozalinone

Piperazines	2C-B-BZP • BZP • GBR-12783 • GBR-12935 • GBR-13069 • GBR-13098 • GBR-13119 • MeOPP • MBZP • Vanoxerine

Piperidines	2-Benzylpiperidine • Desoxypipradrol • Diphemethoxidine • Ethylphenidate • HDMP-28 • (-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate • Methylphenidate (Dexmethylphenidate) • Nocaine • Phacetoperane • Pipradrol

Tropanes	3α-Bis-(4-fluorophenyl)methoxytropane • 3α-((4-Chlorophenyl)phenylmethoxy)tropane • 3-Pseudotropyl-4-fluorobenzoate • Altropane • Brasofensine • CFT (WIN 35,428) • β-CIT (RTI-55) • Cocaethylene • Cocaine • β-CPPIT • Dichloropane (RTI-111) • Difluoropine • FE-β-CPPIT • FP-β-CPPIT • PIT • PTT • RTI-31 • RTI-32 • RTI-51 • RTI-112 • RTI-113 • RTI-121 (IPCIT) • RTI-126 • RTI-150 • RTI-171 • RTI-177 • RTI-336 • Tesofensine • Troparil (β-CPT, WIN 35,065-2) • WF-23 • WF-33 • WF-60

Xanthines	Aminophylline • Caffeine • Dimethazan • Paraxanthine • Theobromine • Theophylline

Others	Amineptine • Bemegride • Benzydamine • BPAP • BTQ • Clofenciclan • Cypenamine • Cyprodenate • Diclofensine • Dimethocaine • Diphenyl prolinol • Ethamivan • Fencamfamine • Feprosidnine • Gilutensin • GYKI-52895 • Hexacyclonate • Indanorex • Indatraline • LR-5182 • Mazindol • Mesocarb • Naphthylisopropylamine • Nikethamide • Nomifensine • Phthalimidopropiophenone • Prolintane • Sibutramine • Yohimbine • Zylofuramine

See also Sympathomimetic amines

v • d • e Antiobesity preparations (A08) -- see also anorectic

Centrally acting	Phentermine - Fenfluramine - Amfepramone - Dexfenfluramine - Mazindol - Cathine - Clobenzorex - Sibutramine - cannabinoids (Rimonabant, Taranabant)

Peripherally acting	Orlistat

Contents

Pharmacology

Contraindications

Side effects

See also

References