Dextrorphan

Pharmacology

Dextrorphan is structurally similar to dextromethorphan, and has an affinity for the same receptors in the central nervous system, although with a slight difference in selectivity. While dextromethorphan is a weak non-competitive NMDA receptor antagonist, dextrorphan is a more potent antagonist[1].

It should be noted, however, that due to its potency as an NMDA receptor antagonist, as well as the fact that it is produced as a by-product of DXM metabolization in the body, DXO is thought to be largely responsible for the psychological side-effects that occur at high doses of DXM. These side-effects can include alteration of consciousness, or "cognitive dissociation", which are characteristic of NMDA blockade and which have afforded DXM its potential for use as a recreational drug.

See also

Morphinan (parent drug of dextromethorphan)

Methorphan (racemic mixture of dextromethorphan and levomethorphan)
Dextromethorphan (DXM) (compound that breaks down into dextrorphan)
Levomethorphan (L-isomer of dextromethorphan with opioid activity)
Levorphanol (Metabolite of levomethorphan; levorphanol is the L-isomer of dextrorphan, has opioid activity)

Psychedelic (psychedelic experience)

Hallucinogen (drug that produces visual alterations and is commonly used for this purpose)

Psychedelic Drug (drug that is called 'mind expanding' and includes drugs like LSD)

Dissociatives (drug which reduces (or blocks) signals to the conscious mind from other parts of the brain)
- Nitrous Oxide (short acting dissociative anesthetic that is inhaled for it's euphoric properties)
- Ketamine (compound that acts most similarly to dextrorphan)
- Dextromethorphan (DXM)
- Dextrorphan (DXO)
- Phencyclidine (PCP) (another compound that acts like dextrorphan)

Recreational use of dextromethorphan (use of dextromethorphan for purposes that induce effects caused by dextrorphan)

Whole Opium
Preparations

Diascordium • Dover's Powder • Granulated Opium • Laudanum • Mithridate • Opium • Paregoric • Poppy Straw Concentrate • Poppy tea • Powdered Opium • Raw Opium • Smoking Opium • Theriac

Natural Opiates

Opium Alkaloids see also: Components of Opium	16-Hydroxythebaine • Allocryptopine • Berberine • Bulbocapnine • Canadine • Codamine • Codeine • Coptisine • Coreximine • Corytuberine • Cotarnine • Cryptopine • Cycloartenol • Cycloartenone • Cyclolaudenol • Dehydroreticuline • Dihydrosanguinarine • Eupaverine • Glaucine • Hydrocotarnine • Isoboldine • Isocorypalmine • Laudanidine • Laudanine • Laudanosine • Magnoflorine • Morphine • Narceine • Narceinone • Narcotine • Narcotoline • Neopine • Norlaudanosoline • Norsanguinarine • Noscapine • Oripavine • Oxysanguinarine • Palaudine • Papaverine • Papaveraldine • Papaverrubine B (O-Methyl-Porphyroxine) • Papaverrubine C (Epiporphyroxine) • Papaverrubine D (Porphyroxine) • Perparin • Pseudomorphine • Reticuline • Salutaridine (Sinoacutine) • Sanguinarine • Scoulerine • Somniferine • Stepholidine • Thebaine

Alkaloid Salts Mixtures	Omnopon • Pantopon • Papaveretum • Tetrapon

Semisynthetics

Morphine Family	14-hydroxydihydromorphine {Hydromorphinol) • 2,4-Dinitrophenylmorphine • 6-Methyldihydromorphine • 6-Methylenedihydrodesoxymorphine • Apomorphine • Desomorphine • Diacetyldihydromorphine • Dihydrodesoxymorphine • Dihydroheroin • Dihydromorphine • Dipropanoylmorphine • Ethyldihydromorphine • Heroin (Diamorphine) • Heroin-7,8-Oxide • Methyldesorphine • Methyldihydromorphine • Nicomorphine • N-Phenethylnormorphine

Codeine-Dionine Family	Acetylcodeine • Benzylmorphine • Codeine • Desocodeine • Dihydroheterocodeine • Ethylmorphine (Dionine) • Heterocodeine • Isocodeine • Morpholinylethylmorphine (Pholcodine) • Myrophine • Nalodeine

Morphinones	14-Ethoxymetopon • 14-Methoxymetopon • 14-O-Methyloxymorphone • 14-Phenylpropoxymetopon • 14-Hydroxydihydromorphinone (Oxymorphone) • 7-Spiroindanyloxymorphone • 8,14-Dihydroxydihydromorphinone • Acetylmorphone • Ethyldihydromorphinone • Hydromorphinol • Hydromorphinone • Hydromorphone • Hydroxycodeine • Methyldihydromorphinone • Metopon • Morphinol • Morphinone • N-Phenethyl-14-ethoxymetopon • Oxymorphone • Semorphone

Codeinones	1-carboxy-14-hydroxydihydrocodeinone • 1-carbethoxy-14-hydroxydihydrocodeinone • 14-Hydroxydihydrocodeinone (Oxycodone) • Acetyldihydrocodeinone • Codeinone • Codorphone • Codoxime • Dihydrocodeinone enol acetate • Dihydrohydroxycodeinone • Hydrocodone • Oxycodone • Thebacon

Dihydrocodeine Series	14-hydroxydihydrocodeine • Acetyldihydrocodeine • Dihydrocodeine • Dihydrodesoxycodeine/Desocodeine • Dihydroisocodeine • Nicocodeine • Nicodicodeine

Nitrogen Morphine Derivatives	Codeine-N-Oxide • Heroin-N-Oxide • Hydromorphone-N-Oxide • Morphine-N-Oxide

Others	α-chlorocodide • Azidomorphine • Chloromorphide • Hydromorphazone • Morphazone • Oxymorphazone • Pholcodine

Active Opiate
Metabolites

Codeine-N-Oxide (Genocodeine) • Hydromorphone-N-Oxide • Heroin-7,8-Oxide • Morphine-3-glucuronide • Morphine-6-glucuronide • Monoacetylmorphine • Morphine-N-Oxide (Genomorphine) • Naltrexol • Norcodeine • Normorphine

Contents

Chemistry

Pharmacology

See also

External links