Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]
While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.[4]
References
^ I. Israely, R. M. Costa, C. w. Xie, A. J. Silva, K. S. Kosik and X. Liu "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction" in Current Biology (2004) Volume 14, pages 1657-1663. Entrez PubMed15380068
^ M. E. Rubio, C. Curcio, N. Chauvet and J. L. Bruses. "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1" in Molecular and Cellular Neurosciences (2005) Volume 4, pages 611-623. Entrez PubMed16456928
^ J. L. Teo, H. Ma, C. Nguyen, C. Lam and M. Kahn. "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation" in Proceedings of the National Academy of Sciences of the United States of America (2005) Volume 102, pages 12171-12176. Entrez PubMed16093313
^ M. Perez-Moreno, M. A. Davis, E. Wong, H. A. Pasolli, A. B. Reynolds, E. Fuchs. "p120-catenin mediates inflammatory responses in the skin" in Cell (2006) Volume 124, pages 631-644. Entrez PubMed16469707
