Cystathionine gamma-lyase

Cystathionine gamma-lyase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cystathionine_gamma-lyase".

content

cystathionase (cystathionine gamma-lyase)
Identifiers
Symbol	CTH
Entrez	1491
HUGO	2501
OMIM	607657
RefSeq	NM_001902
UniProt	P32929
Other data
EC number	4.4.1.1
Locus	Chr. 1 p31.1

Cystathionine gamma-lyase (or cystathionase) is an enzyme which breaks down cystathionine into cysteine and α-ketobutyrate. Pyridoxal phosphate is a prosthetic group of this enzyme.

Pathology

An deficiency is associated with cystathioninuria.

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v • d • e Carbon-sulfur lyases (EC 4.4)

Cystathionine gamma-lyase - Cystathionine-beta-lyase - Leukotriene C4 synthase

v • d • e

glycine→serine→	Serine hydroxymethyltransferase - Serine dehydratase

alanine→	Alanine transaminase

cysteine→	D-cysteine desulfhydrase

threonine→	L-threonine dehydrogenase


HISTIDINE→	Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase

proline→	Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1

arginine→	Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase

→alpha-ketoglutarate→TCA	Glutamate dehydrogenase


PHENYLALANINE→tyrosine→	Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase


asparagine→aspartate→	Asparaginase/Asparagine synthetase - Aspartate transaminase

Other

see also disorders, intermediates