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Corticotropin-releasing hormone receptor
Corticotropin-releasing hormone receptor (CRHR ) is a G protein-coupled receptor that binds corticotropin-releasing hormone (CRH) .[1] gene (CRHR1 CRHR2
Function The CRHR is an important mediator in the stress response.[2] anterior lobe of the pituitary gland known as corticotropes express the receptor and will secrete adrenocorticotropic hormone (ACTH) when stimulated.[3]
References
^ Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi :10.1124/pr.55.1.3 PMID 12615952 . ^ Grammatopoulos DK, Chrousos GP (2002). "Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists". Trends Endocrinol. Metab. 13 (10): 436–44. doi :10.1016/S1043-2760(02)00670-7 PMID 12431840 . ^ Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). "Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system". Neuroendocrinology 43 (1): 79–88. PMID 3012395 .
External links
Transmembrane receptor : G protein-coupled receptors
Class A : Rhodopsin like
GPR (
1 ,
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6 ,
12 ,
15 ,
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182 )
Adenosine (
A1 ,
A2a ,
A2b ,
A3 ) •
P2Y (
1 ,
2 ,
4 ,
5 ,
6 ,
8 ,
9 ,
10 ,
11 ,
12 ,
13 ,
14 )
Other
Acetylcholine (
M1 ,
M2 ,
M3 ,
M4 ,
M5 ) •
Adrenomedullin •
Anaphylatoxin (
C3a ,
C5a ) •
Angiotensin (
1 ,
2 ) •
Apelin •
Bile acid •
Bombesin (
BRS3 ,
GRPR ,
NMBR ) •
Bradykinin (
B1 ,
B2 ) •
Cannabinoid (
CB1 ,
CB2 ) •
Chemokine •
Cholecystokinin (
A ,
B ) •
Dopamine (
D1 ,
D2 ,
D3 ,
D4 ,
D5 ) •
EBI2 •
Endothelin (
A ,
B ) •
Estrogen •
Formyl peptide (
1 ,
L1 ,
L2 ) •
Free fatty acid (
1 ,
2 ,
3 ,
4 ) •
FSH •
Galanin (
1 ,
2 ,
3 ) •
Gonadotropin-releasing hormone (
1 ,
2 ) •
Ghrelin •
Histamine (
H1 ,
H2 ,
H3 ,
H4 ) •
Kisspeptin •
Luteinizing hormone/choriogonadotropin •
Lysophospholipid (
1 ,
2 ,
3 ,
4 ,
5 ,
6 ,
7 ,
8 ) •
MAS (
1 ,
1L ,
D ,
E ,
F ,
G ,
X1 ,
X2 ,
X3 ,
X4 ) •
Melanocortin (
1 ,
2 ,
3 ,
4 ,
5 ) •
MCHR (
1 ,
2 ) •
Melatonin (
1A ,
1B ) •
Motilin •
Neuromedin (
B ,
U (
1 ,
2 )) •
Neurotensin (
1 ,
2 ) •
Opioid (
Delta ,
Kappa ,
Mu ,
Nociceptin , but not
Sigma ) •
Olfactory •
Opsin (
3 ,
4 ,
5 ,
1LW ,
1MW ,
1SW ,
RGR ,
RRH ) •
Orexin (
1 ,
2 ) •
Oxytocin •
Oxoglutarate •
PAF •
Prokineticin (
1 ,
2 ) •
Prolactin-releasing peptide •
Protease-activated (
1 ,
2 ,
3 ,
4 ) •
Relaxin (
1 ,
2 ,
3 ,
4 ) •
Somatostatin (
1 ,
2 ,
3 ,
4 ,
5 ) •
SREB •
Succinate •
TAAR (
1 ,
2 ,
3 ,
5 ,
6 ,
8 ,
9 ) •
Tachykinin (
1 ,
2 ,
3 ) •
Thyrotropin •
Thyrotropin-releasing hormone •
Urotensin-II •
Vasopressin (
1A ,
1B ,
2 )
Class B : Secretin like
GPR (
56 ,
64 ,
97 ,
98 ,
110 ,
111 ,
112 ,
113 ,
114 ,
115 ,
116 ,
123 ,
124 ,
125 ,
126 ,
128 ,
133 ,
143 ,
144 ,
157 )
Other
Brain-specific angiogenesis inhibitor (
1 ,
2 ,
3 ) •
Cadherin (
1 ,
2 ,
3 ) •
Calcitonin •
CALCRL •
CD97 •
Corticotropin-releasing hormone (
1 ,
2 ) •
EMR (
1 ,
2 ,
3 ) •
Glucagon (
GR ,
GIPR ,
GLP1R ,
GLP2R ) •
Growth hormone releasing hormone •
PACAPR1 •
GPR •
Latrophilin (
1 ,
2 ,
3 ,
ELTD1 ) •
Parathyroid hormone (
1 ,
2 ) •
Secretin •
Vasoactive intestinal peptide (
1 ,
2 )
Class C : Metabotropic glutamate / pheromone
TAS1R (
1 ,
2 ,
3 ) •
TAS2R (
1 ,
3 ,
4 ,
5 ,
8 ,
9 ,
10 ,
12 ,
13 ,
14 ,
16 ,
38 ,
39 ,
40 ,
41 ,
43 ,
44 ,
45 ,
46 ,
47 ,
48 ,
49 ,
50 )
Other
Calcium-sensing receptor •
GABA B (
1 ,
2 ) •
Glutamate receptor (
Metabotropic glutamate (
1 ,
2 ,
3 ,
4 ,
5 ,
6 ,
7 ,
8 )) •
GPRC6A •
GPR (
156 ,
158 ,
179 ) •
RAIG (
1 ,
2 ,
3 ,
4 )
Frizzled / Smoothened
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