Cefamandole
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Cefamandole
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}- 3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo- 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number	34444-01-4 42540-40-9 (nafate)
ATC code	J01DC03
PubChem	456255
Chemical data
Formula	C18H18N6O5S2
Mol. mass	462.505 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	75%
Metabolism	?
Half life	48 minutes
Excretion	Mostly renal, as unchanged drug
Therapeutic considerations
Pregnancy cat.	B1(AU)
Legal status	POM(UK) Discontinued (US)
Routes	Intramuscular, intravenous

Cefamandole (INN, also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.

Cefamandole is no longer available in the United States.

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