Calcidiol
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Calcidiol
IUPAC name	(6R)-6-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(5S)-5- Hydroxy-2-methylidene-cyclohexylidene] ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro- 1H-inden-1-yl]-2-methyl-heptan-2-ol
Other names	25-Hydroxyvitamin D3 25-Hydroxycholecalciferol Calcifediol
Identifiers
CAS number	[19356-17-3]
PubChem	5283731
MeSH	Calcidiol
SMILES	C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@] 1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C
Properties
Molecular formula	C27H44O2
Molar mass	400.637 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Calcidiol, calcifediol, 25-hydroxycholecalciferol, or 25–hydroxy–vitamin D, is a prehormone which is produced by the hepatic metabolism (hydroxylation) of vitamin D₃ (cholecalciferol) and which is converted by the kidneys (via 25-Hydroxyvitamin D3 1-alpha-Hydroxylase) into calcitriol (1,25-vitamin D), a steroid hormone. It can also be converted into inactive 24-hydrocalcidiol in the kidneys via 24-hydroxylation.

Clinical significance

In medicine, bloodstream concentration of calcidiol is commonly used to measure overall vitamin D levels. Calcifediol promotes the mineralization of bones and teeth and is used to treat diseases caused by vitamin D deficiency such as rickets and osteomalacia. It is effective even in azotemic patients.^{citation needed}

References

• Dietary Reference intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Institute of Medicine, 1997
• Vitamin D Pharmacology at VitaminDCouncil.com

External links

• A11CC06