CYP51A1

CYP51A1
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content

cytochrome P450, family 51, subfamily A, polypeptide 1
Identifiers
Symbol	CYP51A1
Alt. Symbols	CYP51
Entrez	1595
HUGO	2649
OMIM	601637
RefSeq	NM_000786
UniProt	Q16850
Other data
EC number	1.14.13.70
Locus	Chr. 7 q21.2-21.3

CYP51A1 (or lanosterol 14 alpha-demethylase) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) which converts lanosterol to cholesterol.

See also

Antifungal drug

External links

MeSH cytochrome+P-450+CYP51

This oxidoreductase article is a stub. You can help Wikipedia by expanding it.

v • d • e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase

To Cholesterols	Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1

To Bile acids	Cholesterol 7 alpha-hydroxylase

see also intermediates

v • d • e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)

1.14.11 - 2-oxoglutarate	Prolyl hydroxylase - Lysyl hydroxylase

1.14.13 - NADH or NADPH	Flavin-containing monooxygenase - Nitric oxide synthase (NOS1, NOS2A, NOS3) - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1

1.14.14 - reduced flavin or flavoprotein	19A1 - 2D6 - 2E1

1.14.15 - reduced iron-sulfur protein	11B1 - 11B2 - 11A1

1.14.16 - reduced pteridine	Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase

1.14.17 - reduced ascorbate	Dopamine beta hydroxylase

1.14.18-19 - other	Tyrosinase - Stearoyl-CoA desaturase-1

1.14.99 - miscellaneous	Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)

CYP1	A1, A2, B1

CYP2	A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1

CYP3	A4, A5, A7, A43

CYP4	A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1

CYP5-20	CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)

CYP21-51	CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)

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