CXCR7
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CXCR7".

content
Chemokine (C-X-C motif) receptor 7
Identifiers
Symbols CXCR7; RDC1; CMKOR1; GPR159
External IDs OMIM: 610376 MGI: 109562 HomoloGene: 22419
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57007 12778
Ensembl ENSG00000144476 ENSMUSG00000044337
Uniprot P25106 P56485
Refseq NM_001047841 (mRNA)
NP_001041306 (protein)		 NM_007722 (mRNA)
NP_031748 (protein)
Location Chr 2: 237.14 - 237.16 Mb Chr 1: 92.04 - 92.05 Mb
Pubmed search [1] [2]

Chemokine (C-X-C motif) receptor 7, also known as CXCR7, is a human gene.[1]

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor, it has been later been shown to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12. [1]

References

  1. ^ a b "Entrez Gene: CXCR7 chemokine (C-X-C motif) receptor 7".

Further reading

  • Nagata S, Ishihara T, Robberecht P, et al. (1992). "RDC1 may not be VIP receptor.". Trends Pharmacol. Sci. 13 (3): 102–3. PMID 1315461. 
  • Libert F, Passage E, Parmentier M, et al. (1992). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.". Genomics 11 (1): 225–7. PMID 1662665. 
  • Sreedharan SP, Robichon A, Peterson KE, Goetzl EJ (1991). "Cloning and expression of the human vasoactive intestinal peptide receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4986–90. PMID 1675791. 
  • Law NM, Rosenzweig SA (1994). "Characterization of the G-protein linked orphan receptor GPRN1/RDC1.". Biochem. Biophys. Res. Commun. 201 (1): 458–65. doi:10.1006/bbrc.1994.1723. PMID 8198609. 
  • Shimizu N, Soda Y, Kanbe K, et al. (2000). "A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses.". J. Virol. 74 (2): 619–26. PMID 10623723. 
  • Broberg K, Zhang M, Strömbeck B, et al. (2003). "Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15.". Int. J. Oncol. 21 (2): 321–6. PMID 12118328. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Balabanian K, Lagane B, Infantino S, et al. (2005). "The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.". J. Biol. Chem. 280 (42): 35760–6. doi:10.1074/jbc.M508234200. PMID 16107333. 
  • Infantino S, Moepps B, Thelen M (2006). "Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.". J. Immunol. 176 (4): 2197–207. PMID 16455976. 
  • Burns JM, Summers BC, Wang Y, et al. (2006). "A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.". J. Exp. Med. 203 (9): 2201–13. doi:10.1084/jem.20052144. PMID 16940167. 
  • Proost P, Mortier A, Loos T, et al. (2007). "Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration.". Blood 110 (1): 37–44. doi:10.1182/blood-2006-10-049072. PMID 17363734. 
  • Miao Z, Luker KE, "et al." (2007). "CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.". PNAS 104: 15735–15740. doi:10.1073/pnas.0610444104. 
  • Wang J, Shiozawa Y, Wang J "et al." (2008). "The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer.". J Biol Chem 283: number=4283–4294. doi:10.1074/jbc.M707465200. 
  • Boldajipour B, Mahabaleshwar H, Kardash E et al (2008). "Control of Chemokine-Guided Cell Migration by Ligand Sequestration.". Cell 132: 463-473. doi:10.1016/j.cell.2007.12.034. PMID 18267076. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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G protein-coupled receptors, cytokine receptors: chemokine receptors
CC chemokine receptors
CXC chemokine receptors
CXCR1 - CXCR2 - CXCR3 - CXCR4 - CXCR5 - CXCR6 - CXCR7
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