CRHR1
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CRHR1".

content
Corticotropin releasing hormone receptor 1
Identifiers
Symbols CRHR1; CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f
External IDs OMIM: 122561 MGI: 88498 HomoloGene: 20920
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1394 12921
Ensembl ENSG00000120088 ENSMUSG00000018634
Uniprot P34998 Q0VGH2
Refseq XM_001128344 (mRNA)
XP_001128344 (protein)		 NM_007762 (mRNA)
NP_031788 (protein)
Location Chr 17: 41.24 - 41.27 Mb Chr 11: 103.95 - 103.99 Mb
Pubmed search [1] [2]

Corticotropin releasing hormone receptor 1, also known as CRHR1, is a human gene.

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone (MIM 122560), a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[supplied by OMIM][1]

Contents

See also

References

  1. ^ "Entrez Gene: CRHR1 corticotropin releasing hormone receptor 1".

Further reading

  • Taché Y, Martinez V, Wang L, Million M (2004). "CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome.". Br. J. Pharmacol. 141 (8): 1321–30. doi:10.1038/sj.bjp.0705760. PMID 15100165. 
  • McLean M, Bisits A, Davies J, et al. (1995). "A placental clock controlling the length of human pregnancy.". Nat. Med. 1 (5): 460–3. PMID 7585095. 
  • Polymeropoulos MH, Torres R, Yanovski JA, et al. (1995). "The human corticotropin-releasing factor receptor (CRHR) gene maps to chromosome 17q12-q22.". Genomics 28 (1): 123–4. doi:10.1006/geno.1995.1118. PMID 7590738. 
  • Chen R, Lewis KA, Perrin MH, Vale WW (1993). "Expression cloning of a human corticotropin-releasing-factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8967–71. PMID 7692441. 
  • Ross PC, Kostas CM, Ramabhadran TV (1995). "A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology.". Biochem. Biophys. Res. Commun. 205 (3): 1836–42. doi:10.1006/bbrc.1994.2884. PMID 7811272. 
  • Opdenakker G, Fiten P, Nys G, et al. (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.". Genomics 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328. 
  • Vita N, Laurent P, Lefort S, et al. (1993). "Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors.". FEBS Lett. 335 (1): 1–5. PMID 8243652. 
  • Donaldson CJ, Sutton SW, Perrin MH, et al. (1996). "Cloning and characterization of human urocortin.". Endocrinology 137 (5): 2167–70. PMID 8612563. 
  • Liaw CW, Grigoriadis DE, Lovenberg TW, et al. (1997). "Localization of ligand-binding domains of human corticotropin-releasing factor receptor: a chimeric receptor approach.". Mol. Endocrinol. 11 (7): 980–5. PMID 9178757. 
  • Asakura H, Zwain IH, Yen SS (1997). "Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary.". J. Clin. Endocrinol. Metab. 82 (8): 2720–5. PMID 9253360. 
  • Gottowik J, Goetschy V, Henriot S, et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin.". Neuropharmacology 36 (10): 1439–46. PMID 9423932. 
  • Grammatopoulos D, Dai Y, Chen J, et al. (1998). "Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria.". J. Clin. Endocrinol. Metab. 83 (7): 2539–44. PMID 9661640. 
  • Sakai K, Yamada M, Horiba N, et al. (1998). "The genomic organization of the human corticotropin-releasing factor type-1 receptor.". Gene 219 (1-2): 125–30. PMID 9757017. 
  • Grammatopoulos DK, Dai Y, Randeva HS, et al. (2000). "A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes.". Mol. Endocrinol. 13 (12): 2189–202. PMID 10598591. 
  • Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMID 11416224. 
  • Perrin MH, Fischer WH, Kunitake KS, et al. (2001). "Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor.". J. Biol. Chem. 276 (34): 31528–34. doi:10.1074/jbc.M101838200. PMID 11425856. 
  • Pisarchik A, Slominski AT (2002). "Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression.". FASEB J. 15 (14): 2754–6. doi:10.1096/fj.01-0487fje. PMID 11606483. 
  • Graziani G, Tentori L, Portarena I, et al. (2002). "CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway.". Endocrinology 143 (3): 807–13. PMID 11861501. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • King JS, Bishop GA (2003). "The distribution and cellular localization of CRF-R1 in the vermis of the postnatal mouse cerebellum.". Exp. Neurol. 178 (2): 175–85. PMID 12504877. 

External links

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
α1 (A, B, D), α2 (A, B, C), β1, β2, β3
CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin (DP, EP (1, 2, 3, 4), PGF), Prostacyclin, Thromboxane
B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182)
Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened
 This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
© jGames.co.uk 2007 (some content from Wikipedia under GDL ) !-- ValueClick Media 468x60 and 728x90 Banner CODE for jgames.co.uk -->
Your Ad Here