The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.[1]
Lens SM, de Jong R, Hintzen RQ, et al. (1996). "CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth.". Leuk. Lymphoma18 (1-2): 51–9. PMID 8580829.
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van Baarle D, Kostense S, van Oers MH, et al. (2003). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue.". Trends Immunol.23 (12): 586–91. PMID 12464570.
Dörner T, Lipsky PE (2005). "Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus.". Lupus13 (5): 283–9. PMID 15230280.
