CCRL2

CCRL2
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CCRL2".

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Chemokine (C-C motif) receptor-like 2

Identifiers

CCRL2; CKRX; CRAM-A; CRAM-B; HCR; MGC116710

External IDs

OMIM: 608379 MGI: 1920904 HomoloGene: 2948

Gene ontology
Molecular function:	• rhodopsin-like receptor activity • receptor activity • C-C chemokine receptor activity
Cellular component:	• integral to plasma membrane • membrane
Biological process:	• chemotaxis • signal transduction • G-protein coupled receptor protein signaling pathway • antimicrobial humoral response

Orthologs

Human

Mouse

n/a

ENSMUSG00000043953

n/a

Refseq

NM_003965 (mRNA)
NP_003956 (protein)

XM_979714 (mRNA)
XP_984808 (protein)

Location

n/a

Chr 9: 110.9 - 110.9 Mb

Pubmed search

Chemokine (C-C motif) receptor-like 2, also known as CCRL2, is a human gene.^[1]

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.^[1]

References

^ ^a ^b "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".

Further reading

Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.". Genomics 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512.
Fan P, Kyaw H, Su K, et al. (1998). "Cloning and characterization of a novel human chemokine receptor.". Biochem. Biophys. Res. Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Galligan CL, Matsuyama W, Matsukawa A, et al. (2004). "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.". Arthritis Rheum. 50 (6): 1806–14. doi:10.1002/art.20275. PMID 15188357.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e G protein-coupled receptors, cytokine receptors: chemokine receptors

CC chemokine receptors	CCR1 - CCRL1 - CCR2 - CCRL2 - CCR3 - CCR4 - CCR5 - CCR6 - CCR7 - CCR8 - CCR9 - CCR10

CXC chemokine receptors	CXCR1 - CXCR2 - CXCR3 - CXCR4 - CXCR5 - CXCR6 - CXCR7

Other	CCBP2 - CMKLR1 - CX3CR1 - XCR1

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