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chemokine (C-C motif) ligand 18
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| Identifiers | |
| Symbol | CCL18 |
| Alt. Symbols | SCYA18, DC-CK1, PARC, AMAC-1, DCCK1, MIP-4, CKb7 |
| Entrez | 6362 |
| HUGO | 10616 |
| OMIM | 603757 |
| RefSeq | NM_002988 |
| UniProt | P55774 |
| Other data | |
| Locus | Chr. 17 q11.2 |
Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). CCL18 is approximately 60% identical in amino acid sequence to CCL3. It is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and nonactivated lymphocytes.[1] The gene for human CCL18 contains three exons and is located on chromosome 17.[2][1]
References
- ^ a b Hieshima et al. A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1-alpha/LD78-alpha and chemotactic for T lymphocytes, but not for monocytes. J. Immun. 159: 1140-1149, 1997.
- ^ Tasaki et al. Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1-alpha/LD78-alpha-like genes. Genomics 55: 353-357, 1999.
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