CACNB2
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content
Calcium channel, voltage-dependent, beta 2 subunit
PDB rendering based on 1t0h.
Available structures: 1t0h, 1t0j
Identifiers
Symbols CACNB2; CACNLB2; FLJ23743; MYSB
External IDs OMIM: 600003 MGI: 894644 HomoloGene: 75191
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 783 12296
Ensembl ENSG00000165995 ENSMUSG00000057914
Uniprot Q08289 Q32MF3
Refseq NM_000724 (mRNA)
NP_000715 (protein)		 NM_023116 (mRNA)
NP_075605 (protein)
Location Chr 10: 18.47 - 18.87 Mb Chr 2: 14.52 - 14.9 Mb
Pubmed search [1] [2]

Calcium channel, voltage-dependent, beta 2 subunit, also known as CACNB2, is a human gene.[1]


Contents

See also

References

  1. ^ "Entrez Gene: CACNB2 calcium channel, voltage-dependent, beta 2 subunit".

Further reading

  • Williams ME, Feldman DH, McCue AF, et al. (1992). "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.". Neuron 8 (1): 71–84. PMID 1309651. 
  • Brust PF, Simerson S, McCue AF, et al. (1994). "Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly.". Neuropharmacology 32 (11): 1089–102. PMID 8107964. 
  • Rosenfeld MR, Wong E, Dalmau J, et al. (1993). "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.". Ann. Neurol. 33 (1): 113–20. doi:10.1002/ana.410330126. PMID 8494331. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. 
  • Volsen SG, Day NC, McCormack AL, et al. (1997). "The expression of voltage-dependent calcium channel beta subunits in human cerebellum.". Neuroscience 80 (1): 161–74. PMID 9252229. 
  • Taviaux S, Williams ME, Harpold MM, et al. (1997). "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.". Hum. Genet. 100 (2): 151–4. PMID 9254841. 
  • Robertson HM, Zumpano KL (1998). "Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome.". Gene 205 (1-2): 203–17. PMID 9461395. 
  • Allen TJ, Mikala G (1998). "Effects of temperature on human L-type cardiac Ca2+ channels expressed in Xenopus oocytes.". Pflugers Arch. 436 (2): 238–47. PMID 9594024. 
  • Day NC, Volsen SG, McCormack AL, et al. (1998). "The expression of voltage-dependent calcium channel beta subunits in human hippocampus.". Brain Res. Mol. Brain Res. 60 (2): 259–69. PMID 9757060. 
  • Brice NL, Dolphin AC (1999). "Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line.". J. Physiol. (Lond.) 515 ( Pt 3): 685–94. PMID 10066897. 
  • Gerhardstein BL, Puri TS, Chien AJ, Hosey MM (1999). "Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels.". Biochemistry 38 (32): 10361–70. doi:10.1021/bi990896o. PMID 10441130. 
  • Lie AA, Blümcke I, Volsen SG, et al. (1999). "Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy.". Neuroscience 93 (2): 449–56. PMID 10465427. 
  • Bünemann M, Gerhardstein BL, Gao T, Hosey MM (1999). "Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit.". J. Biol. Chem. 274 (48): 33851–4. PMID 10567342. 
  • Yamaguchi H, Okuda M, Mikala G, et al. (2000). "Cloning of the beta(2a) subunit of the voltage-dependent calcium channel from human heart: cooperative effect of alpha(2)/delta and beta(2a) on the membrane expression of the alpha(1C) subunit.". Biochem. Biophys. Res. Commun. 267 (1): 156–63. doi:10.1006/bbrc.1999.1926. PMID 10623591. 
  • Colecraft HM, Alseikhan B, Takahashi SX, et al. (2002). "Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells.". J. Physiol. (Lond.) 541 (Pt 2): 435–52. PMID 12042350. 
  • Takahashi SX, Mittman S, Colecraft HM (2004). "Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.". Biophys. J. 84 (5): 3007–21. PMID 12719232. 
  • Finlin BS, Crump SM, Satin J, Andres DA (2004). "Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 14469–74. doi:10.1073/pnas.2437756100. PMID 14623965. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Foell JD, Balijepalli RC, Delisle BP, et al. (2004). "Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization.". Physiol. Genomics 17 (2): 183–200. doi:10.1152/physiolgenomics.00207.2003. PMID 14762176. 
  • Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM (2004). "New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel.". J. Biol. Chem. 279 (45): 46367–72. doi:10.1074/jbc.M409523200. PMID 15339916. 

External links

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Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm • Two-pore channel (1, 2)
Ligand-gated
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα (1-6) (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10, 2.1, 2.2, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3, 5.1, 6.1, 6.2, 6.3, 6.4)
Kvα (7-12) (7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 9.1, 9.2, 9.3, 10.1, 10.2, 11.1/hERG, 11.2, 11.3, 12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • MiRP (1, 2, 3) • Shaker gene
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6, L1) • CLNS (1A, 1B)
Cyclic nucleotide-gated
α1, α2, α3, α4, β1, β3, H1, H2, H3, H4
Porin
Other/general
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