Bone morphogenetic protein receptor, type 1

Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. They belong to a class of receptor serine/threonine kinases that bind members of the TGF beta superfamily of ligands-the Bone morphogenetic proteins.

There are two type I BMP receptors: BMPR1A and BPMR1B.

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v • d • e Cell signaling: TGF beta signaling pathway

TGF beta superfamily of ligands	TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal)

TGF beta receptors (Activin, BMP)	TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan

Transducers/SMAD	R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4

Ligand inhibitors	Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1

Coreceptors	BAMBI - Cripto

Other	SARA

v • d • e Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)

2.7.11	Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G Protein kinase C (Protein kinase Mζ) G-protein coupled receptor kinases (Rhodopsin, Beta adrenergic receptor) Ca2+/calmodulin-dependent (Elongation factor 2 kinase, Myosin light-chain) Phosphorylase - Cyclin-dependent Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) MAP3K - GSK-3 - AMP-activated

2.7.12	MAP2K (1, 2, 3, 4, 5, 6, 7)

2.7.1.37, or unknown	Anti-Müllerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B (AKT1, AKT2, AKT3) - PDK1

v • d • e Receptors: growth factor receptors

Nerve growth factors	Low affinity/p75 - high affinity Trk (TrkA, TrkB, TrkC) - Ciliary neurotrophic factor

Somatomedin	Insulin-like growth factor 1 - Insulin-like growth factor 2

CSF	Stem cell factor - Erythropoietin

TGF pathway	TGF-beta (1, 2) - Activin (1, 2) - Bone morphogenetic protein (1, 2)

Other	Hepatocyte growth factor - ErbB/Epidermal growth factor - Fibroblast growth factor (1, 2, 3, 4) - Platelet-derived growth factor (A, B) - VEGF (1, 2, 3)

see also growth factors