Biotin-CoA ligase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Biotin-CoA_ligase".

In enzymology, a biotin-CoA ligase (EC 6.2.1.11) is an enzyme that catalyzes the chemical reaction

ATP + biotin + CoA AMP + diphosphate + biotinyl-CoA

The 3 substrates of this enzyme are ATP, biotin, and CoA, whereas its 3 products are AMP, diphosphate, and biotinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is biotin:CoA ligase (AMP-forming). Other names in common use include biotinyl-CoA synthetase, biotin CoA synthetase, and biotinyl coenzyme A synthetase. This enzyme participates in biotin metabolism.

References

• IUBMB entry for 6.2.1.11
• BRENDA references for 6.2.1.11 (Recommended.)
• PubMed references for 6.2.1.11
• PubMed Central references for 6.2.1.11
• Google Scholar references for 6.2.1.11
• CHRISTNER JE, SCHLESINGER MJ, COON MJ (1964). "ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION". J. Biol. Chem. 239: 3997–4005. PMID 14257635. 

External links

The CAS registry number for this enzyme class is 37318-60-8.

• IUBMB entry for 6.2.1.11

• KEGG entry for 6.2.1.11

• BRENDA entry for 6.2.1.11

• NiceZyme view of 6.2.1.11

• EC2PDB: PDB structures for 6.2.1.11

• PRIAM entry for 6.2.1.11

• PUMA2 entry for 6.2.1.11

• IntEnz: Integrated Enzyme entry for 6.2.1.11

• MetaCyc entry for 6.2.1.11

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047707: biotin-CoA ligase

• AMIGO entry for GO code 0047707: biotin-CoA ligase

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