Betaine-homocysteine methyltransferase

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betaine-homocysteine methyltransferase
Identifiers
Symbol	BHMT
Entrez	635
HUGO	1047
OMIM	602888
RefSeq	NM_001713
UniProt	Q93088
Other data
Locus	Chr. 5 q13.1-q15

betaine-homocysteine methyltransferase 2
Identifiers
Symbol	BHMT2
Entrez	23743
HUGO	1048
OMIM	605932
RefSeq	NM_017614
UniProt	Q9H2M3
Other data
Locus	Chr. 5 q13

Homocysteine, a potentially cytotoxic amino acid, is remethylated to methionine in two ways:

By Methionine Synthase (MTR): homocysteine + 5-methyltetrahydrofolate ---> methionine + Dihydrofolate

By BHMT: homocysteine + betaine ---> methionine + dimethylglycine

BHMT is expressed most predominantly in the liver and kidney^[1].

External links

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v • d • e Transferase: one carbon transferases (EC 2.1)

2.1.1 - Methyltransferases	N-methyltransferase: Histamine N-methyltransferase - Phenylethanolamine N-methyltransferase - Tryptamine N-methyltransferase - Phosphatidylethanolamine N-methyltransferase O-methyltransferase: 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Catechol-O-methyl transferase homocysteine methyltransferase: Betaine-homocysteine methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase Other: Phosphatidyl ethanolamine methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - DNA methyltransferase

2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases	Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase

2.1.3 - Carboxy- and Carbamoyl transferases	Ornithine transcarbamylase

2.1.4 - Amidino transferases	Arginine:glycine amidinotransferase