BATF (gene)

Gene ontology

Molecular function:

• transcription factor activity
• RNA polymerase II transcription factor activity
• sequence-specific DNA binding
• protein dimerization activity

Cellular component:

• nucleus

Biological process:

• transcription
• regulation of transcription, DNA-dependent
• antimicrobial humoral response

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a human gene.¹

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.¹

References

^ ^a ^b "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like".

Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ (2003). "Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.". Biochem. J. 374 (Pt 2): 423–31. doi:10.1042/BJ20030455. PMID 12809553.
Johansen LM, Deppmann CD, Erickson KD, et al. (2003). "EBNA2 and activated Notch induce expression of BATF.". J. Virol. 77 (10): 6029–40. doi:10.1128/JVI.77.10.6029-6040.2003. PMID 12719594.
Williams KL, Zullo AJ, Kaplan MH, et al. (2003). "BATF transgenic mice reveal a role for activator protein-1 in NKT cell development.". J. Immunol. 170 (5): 2417–26. PMID 12594265.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos.". Oncogene 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209.
Meyer NP, Johansen LM, Tae HJ, et al. (1998). "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1.". Mamm. Genome 9 (10): 849–52. doi:10.1007/s003359900881. PMID 9745044.
Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1997). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors.". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.
Hasegawa H, Utsunomiya Y, Kishimoto K, et al. (1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes.". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.
Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.

External links

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