Weigmann specialized in the study of herpetology and mammalogy. In 1835, he founded, together with other scholars, the zoological periodical Archiv für Naturgeschichte, also known as "Wiegmann's Archive". With Johann Friedrich Ruthe (1788-1859) he wrote an important textbook of zoology called Handbuch der Zoologie, and in 1834 Wiegmann published Herpetologia Mexicana, a monograph on the reptiles of Mexico.