Anti-sp100 antibodies
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Anti-sp100_antibodies".

schematic representation of antibody.

Anti-sp100 antibodies are found in association with primary biliary cirrhosis.1 The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis. 20-30% of patients suffering from primary biliary cirrhosis sp100 Abs.

Immunodominant regions of sp100

  • antigenic region 1 - positions 296-311 - Sequence (I K K E K P F S N S K V E C Q A)
  • antigenic region 2 - positions 332-351 - Sequence (E G S T D V D E P L E V F I S A P R S E)

(Bolded areas represent the core epitope)2

References

  1. ^ Szostecki C, Guldner HH, Netter HJ, Will H (1990). "Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis". J. Immunol. 145 (12): 4338–47. PMID 2258622. 
  2. ^ Blüthner M, Schäfer C, Schneider C, Bautz FA (1999). "Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology". Autoimmunity 29 (1): 33–42. PMID 10052683. 
content
v • d • e
Antibodies: autoantibodies
Anti-nuclear antibody
Anti-cytoplasm antibody
Other
© jGames.co.uk 2007 (some content from Wikipedia under GDL ) !-- ValueClick Media 468x60 and 728x90 Banner CODE for jgames.co.uk -->
Your Ad Here