A respected journalist with more than 25 years experience in television, Sanders began her broadcasting career with SAS-7 in Adelaide as a weather presenter, before moving to Seven Perth, during this time she won two consecutive (1981/1982) Logie Awards for Most Popular Female Personality in Western Australia. She moved to Sydney in 1983 to join Network Ten as a consumer reporter and news presenter before returning to the Seven Network as a news presenter in 1988.
Ann joined the national morning news program 11AM in 1990 and at the helm of that program she travelled to Chernobyl, reporting on the radiation fall-out disaster. Sanders presented the Sydney edition of Seven News in early 1995, before being joined by Ross Symonds in 1998 until she moved to weekends in 2004 where she stayed until May 2006 when she swapped roles with Chris Bath to present the Morning News.