Amprenavir

Amprenavir
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Amprenavir".

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Amprenavir
Systematic (IUPAC) name
tetrahydrofuran-3-yl [3-[(4-aminophenyl)sulfonyl- (2-methylpropyl) amino] -1-benzyl-2- hydroxy-propyl] aminomethanoate
Identifiers
CAS number	161814-49-9
ATC code	J05AE05
PubChem	65016
DrugBank	APRD00605
Chemical data
Formula	C₂₅H₃₅N₃O₆S
Mol. mass	505.628 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	hepatic
Half life	7.1-10.6 hours
Excretion	<3% renal
Therapeutic considerations
Licence data	EU, US
Pregnancy cat.	C(US)
Legal status
Routes	oral

Amprenavir (Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection. It was approved by the Food and Drug Administration on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours. The convenient dosing came at a price, as the dose required is 1,200mg, delivered in eight very large gel capsules.

Production of amprenavir was discontinued by the manufacturer December 31, 2004; a prodrug version (fosamprenavir) is available.

v • d • e Antivirals used against HIV (HAART) (primarily J05)

Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI)	Abacavir (ABC)° · Dexelvucitabine^§ · Emtricitabine (FTC)° · KP-1461^† · Lamivudine (3TC)° · Tenofovir° · Didanosine (ddI) · Zidovudine (AZT) · Apricitabine^† · Stampidine^† · Elvucitabine^† · Racivir^† · Amdoxovir^† · Stavudine (d4T) · Zalcitabine (ddC)^‡

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)	Ateviridine^§ · Capravirine^§ · Efavirenz° · Emivirine^§ · Lodenosine^§ · Nevirapine · Etravirine · Rilpivirine^† · Loviride^‡ · Delavirdine^‡ · Quinotaline^§

Protease Inhibitors (PI)	Atazanavir° · Brecanavir^§ · Fosamprenavir° · Lopinavir° · Darunavir · Nelfinavir · Ritonavir · Saquinavir · Tipranavir · Amprenavir^‡ · Indinavir^‡

Entry/fusion inhibitors	Aplaviroc^§ · Enfuvirtide · Maraviroc · Vicriviroc^† · PRO 140^† · Ibalizumab^†

Integrase inhibitors	Raltegravir · Elvitegravir^†

Maturation inhibitors	Bevirimat^† · Vivecon^†

Combined formulations	Combivir · Atripla · Trizivir · Truvada · Kaletra · Epzicom

Other & experimental agents	Abzyme · Calanolide A · Ceragenin · Cyanovirin-N · Diarylpyrimidines · Epigallocatechin gallate (EGCG) · Foscarnet · Globoidnan A · Griffithsin · Hydroxyurea · Miltefosine · Portmanteau inhibitors · Seliciclib^† · Synergistic enhancers · Tre recombinase · Zinc finger protein transcription factor

°DHHS preferred first-line agent. ^†Undergoing clinical trials, not FDA approved. ^‡Formerly or rarely used agent. ^§Development terminated.

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