Aminocarboxymuconate-semialdehyde decarboxylase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aminocarboxymuconate-semialdehyde_decarboxylase".

In enzymology, an aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) is an enzyme that catalyzes the chemical reaction

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate 2-aminomuconate semialdehyde + CO₂

Hence, this enzyme has one substrate, 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate, and two products, 2-aminomuconate semialdehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming). Other names in common use include picolinic acid carboxylase, picolinic acid decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde, beta-decarboxylase, 2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase, and 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase. This enzyme participates in tryptophan metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F6K and 2HBV.

References

• IUBMB entry for 4.1.1.45
• BRENDA references for 4.1.1.45 (Recommended.)
• PubMed references for 4.1.1.45
• PubMed Central references for 4.1.1.45
• Google Scholar references for 4.1.1.45
• SENOH S (1965). "STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID". J. Biol. Chem. 240: 740–9. PMID 14275130. 

External links

The CAS registry number for this enzyme class is 37289-47-7.

• IUBMB entry for 4.1.1.45

• KEGG entry for 4.1.1.45

• BRENDA entry for 4.1.1.45

• NiceZyme view of 4.1.1.45

• EC2PDB: PDB structures for 4.1.1.45

• PRIAM entry for 4.1.1.45

• PUMA2 entry for 4.1.1.45

• IntEnz: Integrated Enzyme entry for 4.1.1.45

• MetaCyc entry for 4.1.1.45

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0001760: aminocarboxymuconate-semialdehyde decarboxylase

• AMIGO entry for GO code 0001760: aminocarboxymuconate-semialdehyde decarboxylase

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