Alpha 1-antichymotrypsin
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Alpha_1-antichymotrypsin".

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
PDB rendering based on 1as4.
Available structures: 1as4, 1qmn, 2ach, 3caa, 4caa
Identifiers
Symbol(s)	SERPINA3; AACT; ACT; GIG24; GIG25; MGC88254
External IDs	OMIM: 107280 MGI: 105045 HomoloGene: 40658
Gene ontology Molecular Function: • DNA binding • protein binding • chymotrypsin inhibitor activity Cellular Component: • extracellular region • intracellular • nucleus Biological Process: • acute-phase response • inflammatory response • regulation of lipid metabolic process
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	12	20716
Ensembl	ENSG00000196136	ENSMUSG00000021091
Uniprot	P01011	Q91WP6
Refseq	NM_001085 (mRNA) NP_001076 (protein)	NM_009252 (mRNA) NP_033278 (protein)
Location	Chr 14: 94.15 - 94.16 Mb	Chr 12: 104.81 - 104.82 Mb
Pubmed search	[1]	[2]

Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.

It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.^[1]

This enzyme is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.^[2]

Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.^[1]

References

Further reading

External links

• MeSH Alpha+1-antichymotrypsin

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