| content | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Enolase 1, (alpha)
|
||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | ENO1; ENO1L1; MBP-1; MPB1; NNE; PPH | |||||||||||||
| External IDs | OMIM: 172430 MGI: 95393 HomoloGene: 68183 | |||||||||||||
| EC number | 4.2.1.11 | |||||||||||||
|
||||||||||||||
| RNA expression pattern | ||||||||||||||
|
|
||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 2023 | 13806 | ||||||||||||
| Ensembl | ENSG00000074800 | n/a | ||||||||||||
| Uniprot | P06733 | n/a | ||||||||||||
| Refseq | NM_001428 (mRNA) NP_001419 (protein) |
XM_001006583 (mRNA) XP_001006583 (protein) |
||||||||||||
| Location | Chr 1: 8.84 - 8.98 Mb | n/a | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. It is a homodimer composed of 2 alpha subunits.
Contents |
Relationship to Myc-binding protein-1
Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of c-myc protooncogene.[1] Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.
Clinical significance
Alpha-enolase has been identified as an autoantigen in Hashimoto's encephalopathy.[2] Single studies have also identified it as an autoantigen associated with severe asthma[3] and a putative target antigen of anti-endothelial cell antibody in Behçet's disease.[4] Reduced expression of the enzyme has been found in the corneas of people suffering from keratoconus.[5][6]
See also
External links
- Alpha-Enolase Linked to Severe Asthma - medscape news report, 25 aug 2006.
References
- ^ Subramanian A, Miller DM. (2000) Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem. 2000 Feb 25;275(8):5958-65. PMID 10681589 free full text
- ^ Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M. High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy. J Neuroimmunol. 2007 Apr;185(1-2):195-200. Epub 2007 Mar 1. PMID 17335908
- ^ Nahm DH, Lee KH, Shin JY, Ye YM, Kang Y, Park HS. (2006) Identification of alpha-enolase as an autoantigen associated with severe asthma. J Allergy Clin Immunol. 2006 Aug;118(2):376-81. Epub 2006 Jun 9. PMID 16890761 doi:10.1016/j.jaci.2006.04.002
- ^ Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D (2003) Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease. Arthritis Rheum 2003, 48:2025-2035. PMID 12847697 free full text
- ^ Srivastava OP, Chandrasekaran D, Pfister RR. Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas. Mol Vis. 2006 Dec 20;12:1615-25. PMID 17200661 free full text
- ^ Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, Orntoft TF. Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. Exp Eye Res 2006; 82:201-9. PMID 16083875
 |
This lyase article is a stub. You can help Wikipedia by expanding it. |
|
|||||
