Hegenberger graduated from the Massachusetts Institute of Technology as an aeronautical engineer and served as a flight instructor during World War I. Later, as Chief of the Instrument Branch, Air Service Engineering Division, at McCook Field in Dayton, Ohio, he began researching flight and navigation instrument development.
Hegenberger went on to develop a blind instrument landing system. In 1932 he made the world's first solo instrument-only flight at Wright Field, in Dayton, Ohio. His system was adopted for both military and civilian use and became standard equipment in all larger airplanes and at all airports. This achievement earned him a second Distinguished Flying Cross and the Collier Trophy in 1934.