As Governor of the northern state of Sonora he lead the Revolution of Agua Prieta that put an end to the presidency of Venustiano Carranza who was killed during the revolt. It was then that de la Huerta was appointed interim President by congress.
One of the most important events that happened during de la Huerta's presidency was the surrender of the notorious Francisco Villa and his army.
He also led a failed revolt in 1923 against president Álvaro Obregón in which most of the army supported him. Obregón had to dissolve the revolt personally.