Aconitic acid
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Aconitic acid
Identifiers
CAS number	[499-12-7]
PubChem	309
MeSH	Aconitate
Properties
Molecular formula	C6H6O6
Molar mass	174.108 g/mol
Appearance	colourless crystals
Melting point	198-199°C (decomp)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Aconitic acid is an organic acid. The conjugate base of aconitic acid, aconitate is a substrate of the citric acid cycle. It is acted upon by aconitase.

Aconitic acid can be synthesized by dehydration of citric acid using sulfuric acid:^[1]

(HO₂CCH₂)₂COH(CO₂H) → HO₂CCH=C(CO₂H)CH₂CO₂H + H₂O

It was first prepared by thermal dehydration.^[2]

References

1. ^ William F. Bruce (1943). "Acontinic Acid". Org. Synth.; Coll. Vol. 2: 12. 
2. ^ B. Pawolleck,"Substitutionsproducte der Citronensäure und ein Versuch zur Synthese der letzteren" Justus Liebig's Annalen der Chemie 1875, volume 178, 150-170. doi:10.1002/jlac.18751780203

v • d • e Citric Acid Cycle Metabolic Pathway
Oxaloacetate Malate Fumarate Succinate Succinyl-CoA Acetyl-CoA NADH + H+ NAD+ H2O FADH2 FAD CoA + ATP(GTP) Pi + ADP(GDP) + H2O NADH + H+ + CO2 CoA NAD+ H2O H2O NAD(P)+ NAD(P)H + H+ CO2 Citrate cis-Aconitate Isocitrate Oxalosuccinate α-Ketoglutarate

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