Acetoacetyl CoA

Acetoacetyl CoA
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Acetoacetyl_CoA".

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Acetoacetyl-CoA

Identifiers
CAS number	[1420-36-6]
PubChem	74
MeSH	acetoacetyl+CoA
Properties
Molecular formula	C₂₅H₄₀N₇O₁₈P₃S
Molar mass	851.609 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Acetoacetyl CoA is precursor of HMG-CoA in the Mevalonate pathway.

It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. (During the metabolism of leucine, this last reaction is reversed.)

Mevalonate pathway

v • d • e Cholesterol metabolic intermediates

to HMG-CoA	Acetyl-CoA - Acetoacetyl-CoA - HMG-CoA

to Dimethylallyl pyrophosphate	Mevalonic acid - Phosphomevalonic acid - 5-Diphosphomevalonic acid - Isopentenyl pyrophosphate - Dimethylallyl pyrophosphate

Geranyl-	Geranyl pyrophosphate - Geranylgeranyl pyrophosphate

To Cholesterol	Farnesyl pyrophosphate - Squalene - 2,3-Oxidosqualene - Lanosterol - (to Ergosterol in fungi)

see also enzymes

v • d • e

histidine→	Urocanic acid - Imidazol-4-one-5-propionic acid - Formiminoglutamic acid - Glutamate-1-semialdehyde

proline→	1-Pyrroline-5-carboxylic acid

arginine→	Ornithine - Putrescine - Agmatine


phenylalanine→tyrosine→	4-Hydroxyphenylpyruvic acid - Homogentisic acid - 4-Maleylacetoacetate

Other


cysteine+glutamate→glutathione	gamma-Glutamylcysteine

glycine→creatine	Glycocyamine - Phosphocreatine - Creatinine

Other	Glycerate 3-phosphate (serine) - Cysteine sulfinic acid

see also enzymes, disorders

See also