The hymn is a prayer for God to remain present with the speaker throughout life, through trials, and through death. The first verse is probably the most well-known:
Thelonious Monk recorded a simple yet remarkably elegant instrumental version of the hymn with his jazz septet under the title "Abide with Me" as start of the 1957 album Monk's Music. In 2006 two different tracks have been reissued as start of the second disc of The Complete 1957 Riverside Recordings, the documentation of the cooperation of Thelonious Monk and John Coltrane.
In an episode of Touched by an Angel Tess develops Alzheimer's Disease, and keeps words "the darkness deepens" while Monica becomes increasing distraught by the illness. When Monica finally accepts Tess's illness, Tess then sings the next line, "Lord, with me abide" and has a miraculous recovery.
In the film A Bridge Too Far, wounded British paratroopers trapped in Arnhem sing this hymn at a field hospital during a ceasefire.
In a flashback during an episode of the television series Lost, this hymn is played on the organ as the character Charlie is in confession.
In The Full Monty Lomper plays "Abide with Me" at his mothers funeral scene.
The Danny Boyle film 28 Days Later has the hymn on its soundtrack: A female solo rendition can be heard in the background of the scene where Jim returns to his parents' house in Deptford and finds their bodies.
The hymn appears at the end of the Doctor Who episode "Gridlock", in which "The Old Rugged Cross" also appears. " Abide with Me" also appears on the series 3 soundtrack. The line "change and decay in all around I see" was quoted in the 1980s Doctor Who story Kinda.
In 1991, TV personality Vic Reeves wrote a dance-mixed version of the song on his album, 'I Will Cure You'. The version features dance beats and is of the rave style, popular during the early nineties.
In 1997, "Abide with Me" was recorded by Sir Elton John and included in the album Carnival: Rainforest Foundation Concert. A live version has been broadcast featured in the TV show called An Evening with Elton John.
In the un-completed HBO Series Carnivale (2nd Season), Hawkins grandmother sings "Abide With Me" while she's in the graveyard, showing Hawkins his relatives graves.
ITV are using the tune for their FA Cup coverage, the tune accompanies famous moments from the FA Cup as people build the FA Cup on a hillside.