ACVR1C
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ACVR1C".

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Activin receptor type 1C
Other names: ACTR-IC, Activin receptor-like kinase 7, ALK-7
Genetic data
Gene code: HUGO code:ACVR1C
Protein Structure/Function
Protein type: Serine/Threonine receptor kinase
Domains: GS domain, TS domain, S/T domain
Other
Taxa expressing: Homo sapiens; homologs: many metazoan phyla
Cell types: ubiquitous
Subcellular localization: Plasma membrane
Enzymatic Data
Catalytic activity: ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactor(s): Magnesium or manganese

ACVR1C or ALK-7 transduces signals of Nodal. Nodal binds to ACVR2B and then forms a comlex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.1

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Identifiers
Symbol ACVR1C
Entrez 130399
HUGO 18123
OMIM 608981
RefSeq NM_145259
UniProt Q8NER5
Other data
Locus Chr. 2 q24.2

References

  1. ^ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756, http://molpharm.aspetjournals.org/cgi/content/full/62/1/65. Retrieved on 5 July 2006. 
v • d • e
Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands
TGF beta receptors
(Activin, BMP)
Transducers/SMAD
Ligand inhibitors
Coreceptors
Other
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