ABCC13

ABCC13
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ABCC13".

content

ATP-binding cassette, sub-family C (CFTR/MRP), member 13

Identifiers

ABCC13; C21orf73; PRED6

External IDs

OMIM: 608835

Gene ontology
Molecular function:	• ATP binding • ATPase activity, coupled to transmembrane movement of substances
Cellular component:	• nucleus • membrane • integral to membrane
Biological process:	• transport

Orthologs

Human

Mouse

n/a

Pubmed search

n/a

ATP-binding cassette, sub-family C (CFTR/MRP), member 13, also known as ABCC13, is a human gene.¹

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.¹

See also

References

^ ^a ^b "Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13".

Further reading

Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates.". Annual review of genomics and human genetics 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
Annilo T, Dean M (2005). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages.". Genomics 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Brun ME, Ruault M, Ventura M, et al. (2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.". Gene 312: 41–50. PMID 12909339.
Yabuuchi H, Takayanagi S, Yoshinaga K, et al. (2003). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver.". Biochem. Biophys. Res. Commun. 299 (3): 410–7. PMID 12445816.
Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.". Genomics 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum. Mol. Genet. 5 (10): 1649–55. PMID 8894702.

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v • d • e

Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter

A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)

1-10	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5 Glucose transporter: 2A1 (GLUT1), 2A2 (GLUT2), 2A3 (GLUT3), 2A4 (GLUT4), 2A5 (GLUT5), 2A6 (SLC2A6), 2A8 (GLUT8), 2A9, 2A10, 2A12 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7

11-20	11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2

21-30	22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A1, 30A4, 30A7, 30A8

31-40	31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7

41-45	40A1, 43A1 44A1, 44A2, 44A4, 45A2

O	O1A2, O1B1, O1B3, O2B1, O431, O4A1

Other

Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)

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