March 4, 2251: At 10:52 UTC, Venus will occult Uranus.
In 2252, the planetoidOrcus will have completed one orbit of the Sun since its discovery in 2004, based upon current orbital measurements which give it a period of 248 Earth years.
August 1, 2253: Mercury occults Regulus (last occultation of Regulus by Mercury was on August 13, 364 BC).
June 9, 2255: Transit of Venus.
2256 to 2258: Eris will reach perihelion for the first time since discovery.
2279: Triple conjunction between Jupiter and Saturn.
October 6, 2271: Close conjunction between Venus and Regulus, perhaps occultation of Regulus by Venus.
Sunday, August 28, 2287: The distance between Mars and Earth closes toward its minimum, the closest approach of the two planets since Wednesday, August 27, 2003.
In 2288, the planetoid Quaoar will have completed one orbit of the Sun since its discovery in 2002, based upon current orbital measurements which gives it a period of 286 Earth years.
Other predictions
2217: The Centralia Mine Fire in Centralia, Pennsylvania is predicted to have used up the mine's coal and stop burning.
2295: The US population is predicted to reach its first one billion inhabitants under current growth trends.
2300: Google's plan to index all the world's information and make it searchable could be achieved, according to Eric E. Schmidt.1
Easter
Unless changes are made as to when Easter will occur, in 2285, the Western Easter will fall on March 22 for the first time since 1818.
March 22 is the earliest possible date on which Easter can occur.
Religious Predictions
According to the Jewish interpretation of creation, Adam was created in 3761 BC. It will have been 6,000 years since then in 2239, thereby initiating a spiritual Sabbatical on a global scale lasting a thousand years (the 7th Millennium on the Hebrew Calendar).2
According to Rashad Khalifa, a man who claimed to be a messenger of God, and claimed to discover a divine mathematical miracle in the Quran3, used the Mysterious Initials in the Quran to predict that the world will end in the year 2280.4
Red Dwarf, parts of the series may be set in the 23rd century, evidenced by Lister stating that he is "an enlightened 23rd century guy." However, other episodes imply Lister is from the 21st century or 22nd century, and most of the series is set about 3 million years later.
Skyland, a TV show on Nicktoons Network takes place in 2251.