According to Wang Yangming (1472–1529), the Ming Dynasty philosopher and governor of Jiangxi, China, he intends to use fo–lang–ji cannons in suppressing the rebellion of Prince Zhu Chenhao in this year. This is most likely the earliest reference in China to the breech-loading Frankish culverin.
A large pandemic spreads from the Greater Antilles into Central America, and perhaps as far as Peru in South America. This widespread epidemic kills off much of the indigenous populations in these areas. According to historian Alfred W. Crosby Jr. in his The Columbian Exchange: Biological and Cultural Consequences of 1492, this outbreak is the first widely documented epidemic in the New World.
Central Mexico Amerindians' population - 25.3 million.